Raphael Sanzio was another man without whom the Renaissance would not have been complete. Raphael made several frescos of the Virgin Mary with Child. His Alba Madonna reflects the typical aura of these images.
We see, from left to right, John the Baptist, Jesus Christ, and the Virgin Mary. All three characters look at the cross. Raphael's paintings of Madonna and Child are almost all poignant reflections on the care of a mother for her infant boy when the looming cross foreshadows Christ's death. The same three characters are in this earlier oil painting, the Madonna del prato.
An excellent painting, no? It has an air of sadness to it, doesn't it? I like this one and even had the privilege of seeing it in person once.